Minggu, 29 Mei 2011

[Z278.Ebook] Fee Download Dog psychology: The basis of dog training, by Leon Fradley Whitney

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Dog psychology: The basis of dog training, by Leon Fradley Whitney

  • Published on: 1981
  • Binding: Unknown Binding
  • 203 pages

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14 of 14 people found the following review helpful.
This is the best read I have found yet!!
By Roseanne Willing
I like the approach to this book. The author breaks everything down in "laymen" terms and gives you examples with his own experience as well. He also gives you tips on training (ie. conditioning for upland bird hunting, field trials,guarding) and to let the dog do their natural thing and how to enforce this as positive behavior. My pyrenees is pretty stubborn and after reading other books on "positive reinformcement only" i.e. treats I was starting to get discouraged.It was not doing the trick. but this book states that you need to find the "drive" behind the dog in order for positive reinforcement to work. If you feed them before training, obviously getting a treat won't work because there "drive" food, has already been met.

I was also surprised that many dog owners make the mistake of calling "come" to there dog when he runs away and won't listen to you.(Myself included). This is the wrong thing to do because your conditioning the dog to "run away" by associating the word "come" to it. How to solve this problem... You will have to read the book..

5 of 5 people found the following review helpful.
Excellent, older book, but very modern in it's approach.
By DeHardt
First I'd like to correct the TOTALLY ERRONEOUS statement someone else made in their review that this book used force to achieve anything. That is precisely the opposite of what Dr. Whitney recommends, and I think that person had never even looked at the book.

These methods are fast, simple, easy to follow, and use the dog's own innate wishes to achieve success. For instance, training to sit, down, shake. Place dog on a table - might have to secure him to something if he wants to jump down. Take treat, hold over nose and contine to move it back until dog sits. When it sits, give treat and reward with a "good boy". Does that sound like the dog is forced into position? No, and the rest of the training in the book is similar. Hold treat below table to teach down, hold just out of reach for shake, etc.

He suggests separation from the family as correction, not rewarding bad behavior by lots of attention, simply taking the dog and putting him up when he misbehaves.

Dr. Whitney stresses that training is MUCH MORE EFFECTIVE WHEN THE DOG THINKS UP THE CORRECT BEHAVIOR BY HIMSELF. This is NOT coercive, and it encourages the dog to think.

You won't find a better book, IMO. You'll find modern people who took his basic ideas, changed them a little bit (like adding an operant for a faster sound reward) and wrote a book. They are good too. But in my view, this original book is best for the easiest, most practical advice you'll ever get.

0 of 0 people found the following review helpful.
Excellent for Better Understanding Our Canine Companions
By Seraphine
This is an excellent book for those who want to understand the way a dog thinks. They may live among humans, they may mimic many of our ways, but they are not 4-legged human and we do them a dis-service by treating them as if they were. Dogs are dogs and are much happier when we understand that and treat them as such. That doesn't mean that we stop loving them, or taking care of them, it just means that when we understand why they do what they do, we're better equipped to live more amicably together.

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A Hen in a Fox's Den (Basic Reading Series), by McGraw-Hill Education

Help children master the phonetic code quickly using the Basic Reading Series. The orderly, logical structure enables even struggling readers to learn virtually all the basis sound/symbol and phonic patterns of English by the time they finish Grade 2.

  • Sales Rank: #1374431 in Books
  • Published on: 1999-10-21
  • Number of items: 1
  • Dimensions: 8.46" h x .20" w x 6.38" l,
  • Binding: Paperback
  • 96 pages

About the Author
McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

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Kamis, 26 Mei 2011

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Tommyhawk's Fantasies: No Longer Straight, by Milford Slabaugh

Gay erotic short stories with explicit language. Ten stories of straight men who have gay sex for the first time, and find that they love it. Sometimes it's our hero who's straight, sometimes he's the lucky guy who gets to show the straight man just what he's missing.

Following is an excerpt from "Sex Game Gone Wrong:"

I got the door open with my books in front of me like a girl (just levering them into the room like that, I hadn’t carried them that way) and when I got into the room, they just rolled down my body like so many dented croquet balls, hitting my foot which hurt but I didn’t say a word. I was too busy gaping!

Gregg was spread-eagled on his bed, stark naked, tied by his hands and his feet, and had a dirty, filthy sweatsock stuffed into his mouth!

“Gregg, what the hell?” I asked.

“Mm-mph!” is what he said.

I got the door shut and locked (guys would walk in on you in a dorm if you didn’t; if you didn’t want company you locked your door and if it was unlocked, you were available for company, that was the routine, and I didn’t think Gregg wanted company just now) and went over.

Got the sweatsock out of the mouth and said again, “Gregg, what happened?”

“That bitch!” Gregg sputtered, spitting out sock lint off his tongue. “That freakazoid, skanky, stinking bitch!”

“What happened?”

“We talk at the student union over a coke and she’s all sweet and forgiving.” Gregg said. “I said I was an idiot for going after Maria and she’s nodding like she’s agreeing with me a hundred percent. So I figure, we got some history and I said I could sure use a bit of special comforting just now.”

“So you asked her back to the room.”

“She knew what I meant.” Gregg said. “Can you untie me while I tell you this? Anyway, we get back and she says that she’s going to show me a hotter time than Maria ever thought about and pulls this rope out of her purse. Said she’s going to tie me to the bed and ride me like I’ve never been ridden before. And I’m thinking, all right!”

I was looking at the ties on one hand as he spoke, and sneaked a look down his body. God, that whanger he had on him. I’d seen it a time or two, but this time, he’d had an erection until some time ago, and it was still all fat and distended, not wrinkled up and puckered up inside his body.

“So she gets me naked and she’s mostly naked, just bra and panties, kissed on me, and sucked me a bit, then said, ‘Now get on the bed and I’ll tie you down.’ Didn’t you hear her, that was when you knocked before.” He turned his head, trying to look up into my face.

“No, I didn’t.” I said as I quickly turned my attention back to the knot. Geez, Melanie must have gotten a merit badge in knots! I couldn’t even find the ends on this one! A real Gordian knot or something!

“Anyway, I’m all tied down and she gets off me, bends down and picks up the sweatsock I’d just taken off.” Gregg said. She balled it up and came up to the bed, right where you are now, and she said, ‘This is for dumping me for Maria!’ and she shoved that thing right into my mouth! And then she gets dressed and said, ‘And this is for lying your ass off in the student union just so you could get me back in bed with you!’ And then the bitch just walks out the door! And so here I am, lying in bed naked and feeling relief that at least you’re going to be the one who finds me tied up here. Hey, can you get me untied already?

I felt something snap in me at that. I got up from my position with one hand on the bed, straightening up and I said, “I don’t think so.”

  • Sales Rank: #745546 in eBooks
  • Published on: 2010-10-09
  • Released on: 2010-10-09
  • Format: Kindle eBook

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0 of 0 people found the following review helpful.
Three Stars
By Douglas Braford
It's okay

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Minggu, 15 Mei 2011

[T253.Ebook] Ebook Chester's Way, by Kevin Henkes

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Chester's Way, by Kevin Henkes

Chester and Wilson had their own way of doing things, and they did everything together. When they cut their sandwiches, it was always diagonally. When they rode their bikes, they always used hand signals. If Chester was hungry, Wilson was too. They were two of a kind, and that's the way it was - until indomitable Lilly, who had her own way of doing things, moved into the neighborhood.

  • Sales Rank: #14164 in Books
  • Brand: Greenwillow Books
  • Published on: 1997-09-22
  • Released on: 1997-09-22
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.88" h x .0" w x 8.00" l, .28 pounds
  • Binding: Paperback
  • 32 pages
Features
  • Great product!

From Publishers Weekly
Chester's ways are fairly circumscribed: this young mouse has definite likes and dislikes, and there is no changing his mind. His friend Wilson is just like him; they're quite a pair. Then Lilly moves into the neighborhood. She speaks backwards ("YLLIL MA I"), travels only in disguise and carries a water pistol wherever she goes, "just in case." She intimidates Chester and Wilson, until she terrorizes some bullies who are picking on the two friends. Suddenly, Lilly's ways don't look so bad, and the threesome becomes just as like-minded and inseparable as Chester and Wilson's former twosome. Henkes's vision of friendship captures the essence of the childlike; his mice live in a sunny, imaginative world mixed with secure routines and the safety of known factors. The story unwinds at a deliberate pace; every sentence is either downright funny or dense with playful, deadpan humor. The artist/author, as always, gently grants room for differences between people (the turnaround in A Weekend with Wendell , for example, and the reconciliation between Wedge and his stepfather in Two Under Par ). Behind each book is a wide-open heart, one readers can't help but respond to, that makes all of Henkes's booksand especially this oneof special value to children. Ages 4-up.
Copyright 1988 Reed Business Information, Inc.

From School Library Journal
PreSchool-Grade 2–Kevin Henkes's charming story (Greenwillow Books, 1988) of two friends who are truly "two peas in a pod" comes to life in this quality production. Chester and Wilson do everything the same way, from cutting sandwiches to playing baseball. Then Lilly, of purple plastic purse fame, moves into the neighborhood. Lilly has her own way of doing things, and Chester and Wilson don't know quite what to make of her until the day she uses one of her disguises to frighten off some misbehaving older boys. Chester and Wilson look at Lilly in a new light, and discover that the three of them have more in common than they previously believed, and that perhaps different ways of doing things are just fine. Narrator Laura Hamilton keeps listeners engaged with her terrific intonation and distinct voice for each character. Background music and sound effects enhance the tale. One side of the recording has page-turn signals to help youngsters read along.–Judy Czarnecki, Chippewa River District Library System, Mt. Pleasant, MI
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

Review
"Children will make "Chester's Way their own."--"School Library Journal"The virtues of variety, experimentation, and friendship are deftly handled in the amusing, believable story."--"The Horn Book

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1 of 1 people found the following review helpful.
This is where we meet Lilly!!
By gypsyrebel
Chester likes things his way, and he and his friend Wilson get along because they like things the same way. And then wonderful Lilly moves into the neighborhood and shakes everything up! The boys don't like her different ways at first and avoid her as best as possible, but when Lilly rescues them from some bullies, they realize that Lilly is worth the chaos she brings to their previously very ordered lives, and she's really more fun than chaos.

0 of 0 people found the following review helpful.
Hurray for Henkes!
By Jennifer R Becker
As always Kevin Henkes is charming and funny. I purchased this as a part of our stocking stuffers and my daughter loves it. You simply can't go wrong with Henkes.

2 of 2 people found the following review helpful.
Belly Laughin Four year old!!!
By Peter G. Samek
My four year old loves this book, when Lilly does her stuff my son loses it, he actually gets belly laughs. We read his book five nights in a row when we first got it, and we didn't mind reading it over and over. Lilly really is a crack up. The moral is great. I have since bought "Julius Baby of the World" and we have read this the past three nights in a row, and we look forward to reading more by Kevin Henkes.

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Rabu, 11 Mei 2011

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Equity Carve-outs: Motives, implementation and the reaction of the stock market, by J?rg Endres

Diplomarbeit, die am 15.12.2001 erfolgreich an einer Universit?t in Deutschland eingereicht wurde. Abstract: As especially in the 1990s corporations today still reconsider their organisational and ownership structures to become more competitive and profitable. Corporate restructuring, however, is not a value creating mechanism per se, but it can enhance corporate flexibility and focus the company on its main line of business. During a restructuring process, the parent firm has several options and choosing the right one in order to be successful is probably one of the most challenging tasks for the management. Options can be utilised to reduce ownership through a Carve-out or eliminate involvement in a Spin-off or Asset Sell-off. A rather unknown form, the Tracking Stock, will also be mentioned and explained. They all added a new dimension to the corporate landscape. Typically, the corporation's aims of restructuring are to create shareholder value. In the last two decades, the tendency was to strengthen the focus on its core businesses and becoming more and more a 'pure player' in its extreme form. The potential of divestiture activities during the next years will still be very high, if one imagines that only in Germany the 30 DAX companies own around 4.500 subsidiaries. One particularly interesting alteration of firm boundaries involves a parent firm partially divesting its ownership stake in a subsidiary via an Equity Carve-out. Equity Carve-outs have become widely known tools for corporations that shed divisions, which are no longer part of their core business. Especially during the last years high growth segments with tremendous potential could be unlocked through this form of divestiture. One of the main advantages for the parent is that it can still benefit from the growth of its subsidiary, by selling only a portion of the new entity in an IPO. Furthermore the subsidiary can gain new resources through a cap

  • Sales Rank: #14560802 in Books
  • Published on: 2001-01-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.40" h x .24" w x 7.36" l, .34 pounds
  • Binding: Paperback
  • 106 pages

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Minggu, 08 Mei 2011

[H845.Ebook] Fee Download Netter's Concise Orthopaedic Anatomy E-Book, Updated Edition (Netter Basic Science), by Jon C. Thompson

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Netter's Concise Orthopaedic Anatomy E-Book, Updated Edition (Netter Basic Science), by Jon C. Thompson

Netter’s Concise Orthopaedic Anatomy is a best-selling, portable, full-color resource excellent to have on hand during your orthopaedic rotation, residency, or as a quick look-up in practice. Jon C. Thompson presents the latest data in thoroughly updated diagnostic and treatment algorithms for all conditions while preserving the popular at-a-glance table format from the previous edition. You’ll get even more art from the Netter Collection as well as new radiologic images that visually demonstrate the key clinical correlations and applications of anatomical imaging. For a fast, memorable review of orthopaedic anatomy, this is a must-have.

  • Maintains the popular at-a-glance table format that makes finding essential information quick and convenient.
  • Contains useful clinical information on disorders, trauma, history, physical exam, radiology, surgical approaches, and minor procedures in every chapter.
  • Lists key information on bones, joints, muscles, and nerves in tables correlate to each Netter image.
  • Highlights key material in different colors—pearls in green and warnings in red—for easy reference.
  • Features both plain film and advanced radiographic (CT and MRI) images, along with cross-sectional anatomic plates for an even more thorough visual representation of the material.


This "updated" second edition includes test-yourself images and notes.  All other content is the same as the 2010 2nd edition.

  • Sales Rank: #174780 in eBooks
  • Published on: 2015-07-24
  • Released on: 2015-07-24
  • Format: Kindle eBook

Review

A clear and concise visual reference on orthopaedic anatomy

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22 of 22 people found the following review helpful.
Kindle iPad Version Near-Useless
By Jo Aska
I own the paper and kindle version, and use it on an iPad, Kindle Fire and Galaxy S3. In the kindle version, each "page" is actually a single scanned picture. This means you cannot highlight / annotate the text. It is also very slow to load. On the iPad, there is some technical error where the software will get into "load screen" loops; extremely annoying when trying to use the text as a reference. On the Kindle Fire and S3, the book is much slower to use than other books due to the size and use of images instead of text. You also cannot search the text.

Content is still great but the Kindle version is subpar.

13 of 13 people found the following review helpful.
Excellent Reference
By rwizard
Purchased as a personal reference, and as a visual aid in explaining things to patients who have questions about their problems. Just received the book early this morning, and began going through it. This book is excellent. I really like the fact that this is about orthopedics and only orthopedics. Previously I had used a set of the Netter flash cards for this purpose, but a colleague showed me this, and it was much better for our purposes. Unlike the flash cards, this is a handy "all in one" reference, and it is not cluttered up with information unrelated to my area of practice. Also, I can drop it in the pocket of my lab coat if I want to take it along. No cards to fumble through or misplace. If you are working in orthopedics, or planning to do so, I would recommend this book without reservation.

13 of 14 people found the following review helpful.
Five star book, 1 star kindle edition
By nicksain
This book is amazing and essential. The kindle edition is pretty poor. No search, links don't work, crashes the app constantly. You're better off with the hard copy.

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Jumat, 06 Mei 2011

[H292.Ebook] Download Where the Action Is: The Foundations of Embodied Interaction (MIT Press), by Paul Dourish

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Where the Action Is: The Foundations of Embodied Interaction (MIT Press), by Paul Dourish

Computer science as an engineering discipline has been spectacularly successful. Yet it is also a philosophical enterprise in the way it represents the world and creates and manipulates models of reality, people, and action. In this book, Paul Dourish addresses the philosophical bases of human-computer interaction. He looks at how what he calls "embodied interaction" -- an approach to interacting with software systems that emphasizes skilled, engaged practice rather than disembodied rationality -- reflects the phenomenological approaches of Martin Heidegger, Ludwig Wittgenstein, and other twentieth-century philosophers. The phenomenological tradition emphasizes the primacy of natural practice over abstract cognition in everyday activity. Dourish shows how this perspective can shed light on the foundational underpinnings of current research on embodied interaction. He looks in particular at how tangible and social approaches to interaction are related, how they can be used to analyze and understand embodied interaction, and how they could affect the design of future interactive systems.

  • Sales Rank: #686340 in Books
  • Brand: Brand: The MIT Press
  • Published on: 2004-08-20
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.00" h x .50" w x 6.00" l, .74 pounds
  • Binding: Paperback
  • 248 pages
Features
  • Used Book in Good Condition

Review

Human-computer interaction meets philosophical treatments of embodiment. The result: a foundational study of living and acting in a wired world. And a rare achievement too: a readable and engaging book which manages to be both sensible and groundbreaking at the same time.

(Andy Clark, Department of Philosophy, University of Edinburgh)

A revolution in design and the role of computer science is upon us: Where the Action Is describes the way. In the old days, the focus was upon the technology and 'computing,' hence the interest is the interface between humans and machines -- us versus them. Not anymore. As Dourish so cogently explains, design should not be about tasks and their requirements, or applications, or computing--design is really about interaction, with a focus on ubiquity, tangibility, and most of all, shared awareness, intimacy, and emotions. This is a revolution badly needed: It's about time.

(Donald A. Norman, Norman Nielsen Group and UNext Learning Services, author of The Invisible Computer)

Where the Action Is provides intellectual foundations for the emerging movement that makes people, and not machines, central to the process of design. With a clarity and thoughtfulness that make hard ideas easy, Paul Dourish's book will only increase in importance as the social nature of computing becomes evident to a new generation of technologists.

(Philip E. Agre, Department of Information Studies, University of California, Los Angeles)

Engagingly written....

(R. Keith Sawyer Philosophical Psychology)

Important reading for anyone engaged in designing computer-based systems to support human activities... full of interesting ideas and insights.

(Richard Mateosian IEEE Micro)

In this beautifully written book, Paul Dourish synthesizes conceptual resources drawn from across the humanities, social and computing sciences, in a way that is generative for our thinking about human/artifact relations. He surveys an intellectual terrain that provides both theoretical and practical support for new forms of engagement across the disciplines, and with the objects of creative technical practice. This book will be a resource not only for designers in human-computer interaction and computer-supported cooperative work but also for scholars of science and technology interested in understanding those worlds from a deeply insightful, reflective practitioner's point of view.

(Lucy Suchman, Professor, Centre for Science Studies, Lancaster University)

This is the first book to provide a broad view of how our interaction with computers is intertwined with our physical world. Dourish gives a wealth of examples of innovations in computer technologies, along with a deep grounding in the philosophical, psychological, and sociological issues and theories. The book is unique in combining great breadth of intellectual underpinnings with a clear explanation that elucidates the relationships between the fields without falling prey to the jargon of either. Everyone interested in seeing where computer interaction is leading us in the coming century will benefit from the wide view and clear perspective that Dourish presents.

(Terry Winograd, Professor of Computer Science, Stanford University)

About the Author

Paul Dourish is Professor of Informatics at the University of California, Irvine, with courtesy appointments in Computer Science and in Anthropology.

Most helpful customer reviews

9 of 9 people found the following review helpful.
Clear, interesting, inspiring, but also a little like a religion
By twark maine
One of the strong sides of this book is that it makes it really easy for the reader - things are generally summarized and repeated exactly in the right places. It can serve as an introduction to the world of phenomenology, sociology and philosophy as pertaining to Human-Computer Interfaces.
It felt more like a mixture between a proposal and an introductory philosophical treatise than an overview of the current state of the field (it carries the word "foundations" in its title for a reason).
After reading it however, I still wasn't convinced that "social computing", "tangible computing" and "embodied interaction" really add up to a construct that can effectively inform the design of new HCI devices even though this claim was repeated throughout the book almost like a prayer wheel.
Interestingly, while the book points out the meaning of embodiment in already existing work practices, it fails to give any strategies on how these theories can actually be applied to the design of effective new HCI devices that go beyond the shiny toys produced at MIT Media Lab.
The loophole seems to be that embodied practices can only arise once the tools are defined, so that it is hard to predict what practices will be used once it's out there - since the way we use tools is largely improvisatory, as Dourish points out.
I also can not stop to wonder if the term "embodiment" is akin to "multimedia" - a belief system that can mean so many things that it effectively disintegrates sooner or later.

So, while it left me not exactly sure that there really is another end to it, it was certainly worthwhile and inspiring to work through this book in a thorough manner - I now feel courageous enough to put my nose into "Being and Time" by Heidegger.
A friendly way to get your brain going!

4 of 4 people found the following review helpful.
A great book, interesting and clear
By Hussein Ahmed
A very interesting, and yet clear to read and follow book. "Where the action is" was a reading reference for my qualifier exam and after reading it I was hooked up to HCI forever. Very exciting and a "must read" for all HCI researchers.

15 of 21 people found the following review helpful.
This is a major work on the human/computer Interface
By J. T. Riley
This is a major work on the redesign of the human/computer interface. It is well written but very deep. Excellent academic research is clearly demonstrate throughout. I would not say, however, that it is an easy read.
Engineering research does not generally have to be as strongly academically founded as scientific research. The controlling factor is "does it work," not how does it relate to previous work. This tendency leads to problems when it is necessary to do multidisciplinary work involving both engineering and science. The redesign of the human/computer interface is just such a problem.
As an engineer working independently in this field, I have often wished for the time and resources to do proper academic studies. Paul Dourish has now done them for me. All my future publications will have to show consistency with this book, show they are clearly outside the area covered by this book, or show the book is wrong. The last alternative is most unlikely. I think I can show my work, based on Darwinism and ontology, complies with the first option. I am certain that my work will be stronger for this effort.

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Rabu, 04 Mei 2011

[W159.Ebook] Fee Download Theory of Machines and Mechanisms 3rd edition

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Theory of Machines and Mechanisms 3rd edition

  • Sales Rank: #1606481 in Books
  • Published on: 1709
  • Binding: Hardcover

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0 of 0 people found the following review helpful.
Five Stars
By Amazon Customer
Good book

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[W704.Ebook] Fee Download Metal Carcinogenesis Testing: Principles and In Vitro Methods (Biological Methods), by Max Costa

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Metal Carcinogenesis Testing: Principles and In Vitro Methods (Biological Methods), by Max Costa

Metal Carcinogenesis Testing: Principles and In Vitro Methods (Biological Methods), by Max Costa



Metal Carcinogenesis Testing: Principles and In Vitro Methods (Biological Methods), by Max Costa

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Metal Carcinogenesis Testing: Principles and In Vitro Methods (Biological Methods), by Max Costa

Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci­ nogenic metals and their compounds. Mounting experimental evidence has suggested that a number of metals and their compounds are potentially carcinogenic to humans. Since humans are exposed to these potentially carcinogenic metals in industrial situations and through environmental pollution, it is essential that experimental protocols be available to identify the specific metal compounds that are potentially carcinogenic. This book affords a thorough description of the various carcinogenesis test systems available for metals, centering on those that are rapid, inexpensive, and most reliable. The principles are discussed at the level of human exposure, of animal studies, and of research in vitro. Additionally, the molecular mechanisms of metal-induced cancer are considered at each ofthese three levels.In large part, the emphasis rests on the use of in vitro, biochemical and bacterial studies, including tissue culture, because these methods are the basis of the rapid and inexpensive screening of potentially carcinogenic substances.

  • Published on: 2013-12-09
  • Released on: 2013-12-09
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.02" h x .42" w x 5.98" l, .56 pounds
  • Binding: Paperback
  • 169 pages

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By Dave
Page 63 If the metal is attached to a highly lipid soluble moiety, then its dissolution and interaction with biological tissues differs from a metal compound that is relatively lipid insoluble. Page 14 Lipid solubility will allow entrance of the metal by absorption through the skin and blood stream transport. Highly water-soluble metal compounds are not assumed to be very carcinogenic unless they become localized and there is persistent contact with a particular cellular tissue. When eukaryotic cells are broken up, the debris is called Microsomes which contains enzymes such as P450 could be used to explain susceptibility of individual animals to metal carcinogens. Microsomal Benzo[a] pyrene is one of the carcigens found in tobacco smoke to cause cancer. This molecule intercalates in DNA, covalently bonding to the nucleophilic guanine nucleobases and distorts the DNA inducing mutations by perturbing the double-helical DNA structure. This disrupts the normal process of copying DNA and induces mutations, which explains the occurrence of cancer after exposure. This mechanism of action is similar to that of aflatoxin which binds to the N7 position of guanine. See "Cancer Cause and Cure" Yoseph page 65 for further research involving how aflatoxins are involved in cancer. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions.

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Metal Carcinogenesis Testing: Principles and In Vitro Methods (Biological Methods), by Max Costa PDF
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